Key result
Intravenous r-hirudin (0.5 mg/kg) provided a long-lasting anticoagulant effect in nephrectomized dogs during hemodialysis, preventing pressure increases and reducing drops in fibrinogen and platelets.
Why the study?
Does intravenous r-hirudin prevent thrombus formation in Beagle dogs undergoing experimental hemodialysis?
Population
Beagle dogs with bilateral functional nephrectomy undergoing experimental hemodialysis
Design
Preclinical
Follow-up
During hemodialysis
Authors
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Supports r-hirudin anticoagulation in experimental canine hemodialysis; leaves open human translation pending clinical trials.
Does intravenous r-hirudin prevent thrombus formation in Beagle dogs undergoing experimental hemodialysis?
Recombinant hirudin at 0.5 mg/kg provides effective anticoagulation without bleeding complications in a canine model of experimental hemodialysis.
Markwárdt et al. (2009) studied Experimental hemodialysis. r-hirudin was evaluated on Prevention of thrombus formation in extracorporeal circulation. Intravenous r-hirudin (0.5 mg/kg) provided a long-lasting anticoagulant effect in nephrectomized dogs during hemodialysis, preventing pressure increases and reducing drops in fibrinogen and platelets.
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