What question did this study set out to answer?

To determine the role of thrombin in high-flow, platelet-dependent arterial thrombosis and evaluate the antithrombotic and antihemostatic efficacy of hirudin compared to heparin.

March 1, 1991BloodOpen Access

Hirudin interruption of heparin-resistant arterial thrombus formation in baboons

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Authors

AKAB KellyEmory University UMUM MarzecEmory University WKWilliam C. KrupskiLouisiana State University

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Implication

Comparative animal study demonstrates that hirudin interrupts heparin-resistant arterial thrombosis in baboons, indicating that arterial thrombus formation is primarily driven by thrombin.

Key Points

To determine the role of thrombin in high-flow, platelet-dependent arterial thrombosis and evaluate the antithrombotic and antihemostatic efficacy of hirudin compared to heparin.
Evaluated in vivo arterial thrombus formation in baboons across three thrombogenic surfaces: homologous endarterectomized aorta, collagen-coated tubing, and Dacron vascular grafts.
Administered continuous intravenous infusions of recombinant hirudin (1, 5, and 20 nmol/kg/min) or intravenous boluses of heparin (100 and 1,000 U/kg).
Measured platelet deposition using gamma camera imaging of 111In-platelets, fibrin accumulation via circulating 125I-fibrinogen, test-segment occlusion, and bleeding times.
Hirudin produced dose-dependent inhibition of platelet and fibrin accumulation across all thrombogenic surfaces and completely prevented thrombotic occlusion at all doses (1, 5, and 20 nmol/kg/min).
Heparin at 100 U/kg failed to inhibit platelet or fibrin deposition (P > .1), did not prevent vascular occlusion, and did not prolong bleeding times (P > .5).
Tenfold higher heparin dosing (1,000 U/kg) yielded only intermediate antithrombotic effects and slight bleeding time prolongation (P < .05), whereas hirudin prolonged bleeding times at intermediate and high doses.

Cite This Study

Kelly et al. (1991) studied this question.

synapsesocial.com/papers/6a6f9c96febe604dd7087db3 https://doi.org/10.1182/blood.v77.5.1006.1006

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Implication

Comparative animal study demonstrates that hirudin interrupts heparin-resistant arterial thrombosis in baboons, indicating that arterial thrombus formation is primarily driven by thrombin.

Hirudin interruption of heparin-resistant arterial thrombus formation in baboons

Discussion

Member takes

Implication

Key Points

Cite This Study

Hirudin interruption of heparin-resistant arterial thrombus formation in baboons

Discussion

Member takes

Implication

Key Points

Cite This Study

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