Why the study?
Does hirudin reduce platelet deposition on damaged vessel walls compared to heparin in a porcine model under arterial flow conditions?
Does hirudin reduce platelet deposition on damaged vessel walls compared to heparin in a porcine model under arterial flow conditions?
Local thrombin generation at the site of severe vascular injury induces platelet activation and deposition despite therapeutic heparin levels, which can be mitigated by specific thrombin inhibitors like hirudin.
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May support direct thrombin inhibition over heparin for platelet deposition in severe injury; hypothesis-generating for human arterial thrombosis.
Badimón et al. (1991) studied this question.
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