Key result
Specific surgical procedures, such as cholecystectomy and laparotomy, were associated with a greater depletion of postoperative antithrombin III than other common operations.
Why the study?
Does the site of operation affect postoperative antithrombin III concentrations in surgical patients?
Observational (n=305)
Does the site of operation affect postoperative antithrombin III concentrations in surgical patients?
Postoperative depletion of antithrombin III appears to be influenced by the specific site of the operation rather than the overall degree of surgical trauma.
Answers are grounded in this paper and cite their sources.
May support procedure-specific antithrombin monitoring; leaves open impact on thrombotic outcomes or supplementation needs.
Antithrombin III concentrations were measured in 305 patients before and at intervals after operation for up to 12 days. The blood concentrations fell significantly after both major and minor surgery, but there was no relation between the expected degree of surgical trauma or the amount of blood transfused and the fall in concentration of antithrombin III. Some surgical procedures such as cholecystectomy, laparotomy, hernia repair, highly selective vagotomy, and transurethral resection of the prostate were associated with a greater depletion of antithrombin III than were other common operations and it is suggested that there are factors related to the actual site of the operation which affect the concentration of circulating antithrombin III in the postsurgical period.
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Gray et al. (1981) conducted an observational in Postoperative state (n=305). Specific surgical procedures (e.g., cholecystectomy, laparotomy, hernia repair) vs. Other common operations was evaluated on Postoperative antithrombin III concentrations. Specific surgical procedures, such as cholecystectomy and laparotomy, were associated with a greater depletion of postoperative antithrombin III than other common operations.
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