Key result
The Vitros DGXN digoxin immunoassay produced a small positive bias compared to the Roche OnLine method (1.46 vs 1.30 μg/L; P=0.0001) and was slightly interfered with by DLIFs in neonatal samples.
Population
Serum samples from 26 adults receiving digoxin therapy, 44 newborns not receiving digoxin therapy, and…
Comparison
Vitros digoxin immunoassay (DGXN) vs Roche OnLine digoxin assay and Abbott Digoxin II…
Design
Other
Authors
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Small bias and DLIF interference warrant caution in neonatal digoxin monitoring; leaves open standardization of immunoassays.
Observational (n=70)
Yes
Absolute Event Rate: 1.46% vs 1.3%
p-value: p=0.0001
The Vitros digoxin immunoassay is precise and sensitive for clinical use but exhibits a small positive bias and slight interference from endogenous digoxin-like immunoreactive factors, which may occasionally cause discrepant results.
Way et al. (1998) conducted an observational in Digoxin therapy monitoring and DLIF interference (n=70). Vitros DGXN digoxin immunoassay vs. Roche OnLine and Abbott Digoxin II assays was evaluated on Mean digoxin concentration in adult samples (p=0.0001). The Vitros DGXN digoxin immunoassay produced a small positive bias compared to the Roche OnLine method (1.46 vs 1.30 μg/L; P=0.0001) and was slightly interfered with by DLIFs in neonatal samples.
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