Key result
Serum digoxin concentration measured by EIA was significantly higher than by FPIA (1.347 vs. 1.196 ng/ml, mean difference 0.146 ng/ml; 95% CI 0.0261-0.266; p<0.02).
Why the study?
Does dry chemistry EIA on the Vitros 950 yield different serum digoxin concentrations compared to FPIA on the TDxFLx in patient samples?
Population
Patients' sera samples for digoxin concentration measurement
Comparison
Dry chemistry enzyme immunoassay on the Vitros 950 vs Fluorescence polarization immunoassay on the…
Design
Other
Authors
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Method bias may alter digoxin interpretation across labs; leaves open outcome impact and harmonization needs.
Observational
Does dry chemistry EIA on the Vitros 950 yield different serum digoxin concentrations compared to FPIA on the TDxFLx in patient samples?
Mean Difference: 0.146 (95% CI 0.0261–0.266)
Absolute Event Rate: 1.347% vs 1.196%
p-value: p=<0.02
Significant method-dependent differences exist between EIA and FPIA for measuring serum digoxin, necessitating harmonization if both systems are used in the same clinical setting.
Bogdan Solnica (2004) conducted an observational in Serum digoxin concentration monitoring. Dry chemistry enzyme immunoassay (EIA) vs. Fluorescence polarization immunoassay (FPIA) was evaluated on Mean digoxin concentration (MD 0.146, 95% CI 0.0261 to 0.266, p=<0.02). Serum digoxin concentration measured by EIA was significantly higher than by FPIA (1.347 vs. 1.196 ng/ml, mean difference 0.146 ng/ml; 95% CI 0.0261-0.266; p<0.02).
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