Key result
Expanding a dog's blood volume caused a fall in the short-circuit current across an isolated frog skin incorporated into its circulation, indicating a circulating substance alters active sodium transport.
Why the study?
Does expanding a dog's blood volume reduce the short-circuit current across an isolated frog skin incorporated in its circulation?
Does expanding a dog's blood volume reduce the short-circuit current across an isolated frog skin incorporated in its circulation?
Expanding a dog's blood volume alters a circulating substance that decreases active sodium transport across a frog skin.
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Hypothesis-generating for a volume-sensitive natriuretic factor; leaves open its identity and relevance to human disease.
Nutbourne et al. (1970) studied this question. Blood volume expansion vs. No blood volume expansion was evaluated on Short-circuit current across isolated frog skin. Expanding a dog's blood volume caused a fall in the short-circuit current across an isolated frog skin incorporated into its circulation, indicating a circulating substance alters active sodium transport.
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