Key result
Plasma digoxin levels showed no difference between digitalis-toxic and non-toxic patients, indicating that plasma levels may not necessarily indicate toxicity.
Why the study?
Do plasma digoxin levels correlate with clinical digitalis toxicity in patients admitted to the hospital?
Observational
Do plasma digoxin levels correlate with clinical digitalis toxicity in patients admitted to the hospital?
Plasma digoxin levels may not reliably indicate clinical toxicity, especially without standardized timing of blood sampling relative to drug administration.
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Plasma digoxin levels may not reliably indicate toxicity in inpatients; leaves open the value of routine monitoring pending prospective validation.
Howard et al. (1973) conducted an observational in Cardiac intoxication with digitalis. Plasma digoxin levels was evaluated on Digitalis toxicity. Plasma digoxin levels showed no difference between digitalis-toxic and non-toxic patients, indicating that plasma levels may not necessarily indicate toxicity.
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