Key result
Amiloride increased mean renal digoxin clearance from 1.3 to 2.4 ml/kg/min (p<0.001) and suppressed digoxin-induced inotropism.
Why the study?
Does amiloride alter digoxin kinetics and digoxin-induced inotropism in healthy subjects?
Population
6 healthy subjects
Comparison
Digoxin with amiloride pretreatment vs Digoxin alone (without amiloride)
Authors
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May warrant monitoring for digoxin-amiloride interaction; leaves open translation to patients with heart failure.
Does amiloride alter digoxin kinetics and digoxin-induced inotropism in healthy subjects?
Absolute Event Rate: 2.4% vs 1.3%
p-value: p=<0.001
Amiloride significantly alters digoxin pharmacokinetics and abolishes its positive inotropic effect in healthy subjects.
Waldorff et al. (1981) studied this question. Amiloride vs. Without amiloride (digoxin alone) was evaluated on Mean renal digoxin clearance (ml/kg/min) (p=<0.001). Amiloride increased mean renal digoxin clearance from 1.3 to 2.4 ml/kg/min (p<0.001) and suppressed digoxin-induced inotropism.
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