Key result
Cyclical reduction of coronary blood flow was eliminated by inhibitors of prostaglandin E2 synthesis like aspirin, and induced by prostaglandin E2 and epinephrine, indicating the participation of prostaglandin E2.
Why the study?
Do prostaglandin E2 and epinephrine participate in the cyclical reduction of coronary blood flow in partially constricted coronary arteries?
Population
Anesthetized dogs with partially constricted coronary artery
Design
Preclinical
Authors
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No clinical implications from this canine model; leaves open prostaglandin E2 participation in human coronary flow dynamics.
Do prostaglandin E2 and epinephrine participate in the cyclical reduction of coronary blood flow in partially constricted coronary arteries?
Prostaglandin E2 plays a key role in mediating the cyclical reduction of coronary blood flow in partially constricted coronary arteries in a canine model.
Uchida et al. (1978) studied Cyclical reduction of coronary blood pressure and flow (n=156). Prostaglandin synthesis inhibitors (e.g., aspirin) and Prostaglandin E2 vs. Control state (spontaneous cyclical reduction or lack thereof) was evaluated on Elimination or induction of cyclical reduction of coronary blood flow. Cyclical reduction of coronary blood flow was eliminated by inhibitors of prostaglandin E2 synthesis like aspirin, and induced by prostaglandin E2 and epinephrine, indicating the participation of prostaglandin E2.
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