Key result
Halothane abolishes cyclical coronary flow reductions in dogs with stenosed arteries, unlike isoflurane or enflurane.
Why the study?
The effects of halothane, isoflurane, and enflurane on spontaneous and epinephrine-exacerbated cyclical coronary flow reductions in stenosed coronary arteries were unclear.
Does halothane, isoflurane, or enflurane prevent spontaneous and epinephrine-exacerbated cyclical coronary flow reductions in dogs with stenosed coronary arteries?
Comparison
Halothane (1%, 0.5%, 0.25%) vs isoflurane (1.5%) vs enflurane (2.0%) vs control
Design
Preclinical experimental study
Follow-up
Acute during procedure
Authors
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Halothane may reduce acute coronary thrombosis in stenotic models; leaves open clinical translation in anesthesia.
Does halothane, isoflurane, or enflurane prevent spontaneous and epinephrine-exacerbated cyclical coronary flow reductions in dogs with stenosed coronary arteries?
In a canine model of coronary stenosis, halothane, but not isoflurane or enflurane, protects against spontaneous and epinephrine-exacerbated acute thrombus formation.
Bertha et al. (1989) studied Mechanically stenosed coronary artery with cyclical blood flow reductions (n=23). Halothane vs. Isoflurane and enflurane was evaluated on Spontaneous cyclical blood flow reductions. Halothane abolished spontaneous cyclical blood flow reductions in dogs with stenosed coronary arteries, whereas isoflurane and enflurane did not.
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