Why the study?
Does hemoperfusion over Amberlite XAD-4 effectively remove digoxin in an anephric patient?
Does hemoperfusion over Amberlite XAD-4 effectively remove digoxin in an anephric patient?
Hemoperfusion over Amberlite XAD-4 can remove a quantifiable amount of digoxin in an anephric patient, resulting in a modest decrease in serum concentrations.
Limited digoxin removal by hemoperfusion in anephric patients warrants clinical caution; leaves open therapeutic role.
Removal of digoxin by hemoperfusion over Amberlite XAD-4 was determined in a functionally anephric patient. During four hours of hemoperfusion, 50.45 microgram of digoxin were removed by the column and serum digoxin concentrations decreased by 0.2 ng/ml after the post-hemoperfusion reequilibration was complete.
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Gibson et al. (1978) studied this question.
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