Key result
Digoxin-specific F(ab')2 antibody fragments reinstated sinus rhythm in all treated cats with digitoxin-induced ventricular tachycardia, whereas the arrhythmia was fatal in 4 of 5 controls.
Why the study?
Do digoxin-specific F(ab')2 antibody fragments reinstate sinus rhythm in cats with digitoxin-induced ventricular tachycardia?
Do digoxin-specific F(ab')2 antibody fragments reinstate sinus rhythm in cats with digitoxin-induced ventricular tachycardia?
Digoxin-specific F(ab')2 antibody fragments effectively reverse digitoxin-induced ventricular tachycardia in an animal model, suggesting clinical utility for digitoxin poisoning.
Answers are grounded in this paper and cite their sources.
May support antidotal use in feline digitoxin toxicity; leaves open clinical translation.
In animal experiments heterologous digoxin-specific F(ab')2 antibody fragments have been found to be effective for the treatment of arrhythmias induced by toxic doses of digoxin. So far they have been successfully employed in three patients suffering from digoxin poisoning. The present study was undertaken to test whether these antibodies are also effective in the treatment of digitoxin poisoning. Ventricular tachycardia, induced in digitalized cats by intravenous injections of digitoxin, was fatal in four out of five controls. However, sinus rhythm was reinstated in all the animals treated with digoxin-specific F(ab')2 after onset of the arrhythmia. Cross-reactivity between the antibodies used and digitoxin, while slight in vitro, is, nevertheless, sufficient to justify their clinical use in cases of digitoxin poisoning.
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Heß et al. (1980) studied Digitoxin poisoning. Digoxin-specific F(ab')2 antibody fragments vs. Control was evaluated on Reinstatement of sinus rhythm / mortality. Digoxin-specific F(ab')2 antibody fragments reinstated sinus rhythm in all treated cats with digitoxin-induced ventricular tachycardia, whereas the arrhythmia was fatal in 4 of 5 controls.
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