Key result
Following anthracycline chemotherapy, significant longitudinal peak systolic strain reduction occurred in 32.4% of myocardial segments, occurring more frequently in basal segments.
Why the study?
Does 2D strain echocardiography detect segmental myocardial dysfunction in breast cancer patients undergoing anthracycline chemotherapy?
Population
63 patients with breast cancer amenable for anthracycline chemotherapy, mean age 47 ± 10 years.
Comparison
Two-dimensional strain echocardiography before… vs Baseline echocardiography (before chemotherapy)
Design
Cohort
Authors
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Segmental LPSS monitoring may flag early anthracycline cardiotoxicity; leaves open prospective validation of basal predominance.
Observational (n=63)
No
Does 2D strain echocardiography detect segmental myocardial dysfunction in breast cancer patients undergoing anthracycline chemotherapy?
Segmental evaluation of longitudinal peak systolic strain by 2D echocardiography may detect early anthracycline-induced cardiotoxicity, particularly in basal segments, even when global strain is unchanged.
Toufan et al. (2017) conducted an observational in Breast cancer (n=63). Anthracycline chemotherapy vs. Baseline (pre-chemotherapy) was evaluated on Significant reduction (>15%) in longitudinal peak systolic strain (LPSS) across examined myocardial segments. Following anthracycline chemotherapy, significant longitudinal peak systolic strain reduction occurred in 32.4% of myocardial segments, occurring more frequently in basal segments.
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