Key result
A mathematical model of human coronary blood flow demonstrated that the presence of microvascular disease and large vessel stenosis deleteriously affect fractional flow reserve.
Why the study?
Assessing coronary stenosis relies on invasive high-risk surgical assessment to generate fractional flow reserve, highlighting the need for non-invasive computational methods.
Population
An adapted closed loop mathematical model of human coronary blood flow
Comparison
Simulations under focal stenosis, diffuse stenosis, and microvascular disease
Design
In silico computational simulation study
Authors
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May enable non-invasive FFR estimation; leaves open prospective validation before clinical use.
A mathematical model of coronary blood flow suggests that microvascular disease and combined focal/diffuse stenosis significantly impact FFR, while heart rate does not.
Joseph et al. (2022) studied Coronary stenosis and microvascular disease. Mathematical model of coronary blood flow was evaluated on Fractional flow reserve. A mathematical model of human coronary blood flow demonstrated that the presence of microvascular disease and large vessel stenosis deleteriously affect fractional flow reserve.
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