Key result
Pre-surgical oral clonidine significantly reduced total blood loss (120.4 ml vs 158.5 ml, p=0.001) and improved surgical field quality compared to oral atenolol in patients undergoing nasal surgery.
RCT (n=120)
Blinded (implied by decoding at end of study)
Randomly divided
No
Clonidine may reduce blood loss and improve surgical field quality versus atenolol in nasal surgery; leaves open confirmation in larger trials.
Background: Although adequate level of anaesthesia is achieved by various anaesthetic solutions, tachycardia, hypertension and other cardiovascular responses usually occur following nasal speculum insertion due to failure of gaining the adequate hemodynamic response. A reduction in the hemodynamic response to noxious stimulus has been shown by the preoperative use of clonidine (-2 agonist) and atenolol (-blocker) at various stages of surgery. Hence, we evaluated and compared the efficacy of oral clonidine and oral atenolol when given pre-surgically in the patients undergoing nasal surgeries.
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Kumar et al. (2016) conducted an RCT in Nasal surgery (rhinoplasty, septoplasty, functional endoscopic sinus surgery) (n=120). Oral clonidine vs. Oral atenolol was evaluated on Total blood loss (ml) (p=0.001). Pre-surgical oral clonidine significantly reduced total blood loss (120.4 ml vs 158.5 ml, p=0.001) and improved surgical field quality compared to oral atenolol in patients undergoing nasal surgery.
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