Key result
Clonidine administered before aortic surgery significantly suppressed the intraoperative increase in plasma norepinephrine (P<0.001) and epinephrine (P<0.01) compared to placebo.
Why the study?
Does preoperative clonidine reduce intraoperative catecholamine release and improve circulatory stability in patients undergoing aortic surgery?
RCT (n=28)
double-blind
randomly assigned
Does preoperative clonidine reduce intraoperative catecholamine release and improve circulatory stability in patients undergoing aortic surgery?
p-value: p=<0.001
Preoperative oral clonidine suppresses the catecholamine surge and improves hemodynamic stability during aortic surgery, reducing the need for intraoperative interventions.
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Preoperative clonidine may enhance hemodynamic stability in aortic surgery; extends evidence for alpha-2 agonism in major vascular procedures.
Quintin et al. (1990) conducted an RCT in Patients presenting for aortic surgery (n=28). clonidine vs. placebo was evaluated on Plasma catecholamines (epinephrine and norepinephrine) and hemodynamic variables (p=<0.001). Clonidine administered before aortic surgery significantly suppressed the intraoperative increase in plasma norepinephrine (P<0.001) and epinephrine (P<0.01) compared to placebo.
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