Key result
Clonidine did not significantly reduce time to tracheal extubation vs placebo (7.1 vs 8.0 h, P=0.70), but increased the proportion extubated within 4 hours (20% vs 8%, P=0.038).
Why the study?
Does clonidine improve recovery times and haemodynamics in patients undergoing elective CABG surgery?
RCT (n=156)
Double-blind
Randomized
Does clonidine improve recovery times and haemodynamics in patients undergoing elective CABG surgery?
Absolute Event Rate: 7.1% vs 8%
p-value: p=0.70
Clonidine administration during elective CABG surgery facilitates early extubation, reduces anesthetic drug usage, and improves postoperative creatinine clearance and quality of life.
No takes yet. Share an insight, caveat, or question.
Clonidine may increase early extubation after CABG without shortening median time; extends perioperative alpha-2 agonist data but requires confirmation.
Myles et al. (1999) conducted an RCT in Elective CABG surgery (n=156). Clonidine vs. Placebo was evaluated on Time to tracheal extubation (median hours) (p=0.70). Clonidine did not significantly reduce time to tracheal extubation vs placebo (7.1 vs 8.0 h, P=0.70), but increased the proportion extubated within 4 hours (20% vs 8%, P=0.038).
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