Key result
Chronic selective alpha-1 adrenoceptor blockade with prazosin decreased cumulative sodium excretion following a saline load in healthy volunteers (64.1 vs 79.4 mmol/4 hours; P≤.05).
Why the study?
Does chronic prazosin therapy decrease the ability to excrete a saline load in healthy volunteers?
Population
8 healthy volunteers
Comparison
Prazosin 5 mg twice daily for four weeks vs Baseline measurements in the same volunteers
Design
Cohort
Follow-up
4 weeks
Authors
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May impair natriuresis with chronic prazosin; hypothesis-generating for sodium retention mechanisms and needs patient studies.
Does chronic prazosin therapy decrease the ability to excrete a saline load in healthy volunteers?
Absolute Event Rate: 64.1% vs 79.4%
p-value: p=≤.05
Chronic alpha-1 adrenoceptor blockade with prazosin decreases the ability to excrete a saline load in healthy volunteers, providing a mechanistic explanation for clinically observed sodium retention.
Penner et al. (1993) studied Healthy volunteers (n=8). Prazosin vs. Baseline (pre-treatment) was evaluated on Cumulative sodium excretion during and after saline infusion (mmol/4 hours) (p=≤.05). Chronic selective alpha-1 adrenoceptor blockade with prazosin decreased cumulative sodium excretion following a saline load in healthy volunteers (64.1 vs 79.4 mmol/4 hours; P≤.05).
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