Key result
Pretreatment with donor blood and 100 mg/kg cyclophosphamide resulted in permanent heart allograft acceptance in rats, whereas 50 mg/kg abolished immunologic enhancement.
Why the study?
Does pretreatment with donor blood and cyclophosphamide improve heart allograft survival in rat models?
Population
WAG/Rij and BN rats undergoing heart allografts
Comparison
Intravenous pretreatment with donor blood and… vs Donor blood alone or different donor-host…
Design
Preclinical
Authors
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Highlights dose-dependent effects in rat heart transplant models; leaves open clinical translation of donor-specific preconditioning.
Does pretreatment with donor blood and cyclophosphamide improve heart allograft survival in rat models?
Pretreatment with donor blood and cyclophosphamide can induce permanent heart allograft survival in specific rat strain combinations, highlighting dose- and strain-dependent immunomodulatory effects.
Marquet et al. (1975) studied Heart allograft rejection. Donor blood and cyclophosphamide vs. Donor blood alone or reverse donor-host combination was evaluated on Graft survival. Pretreatment with donor blood and 100 mg/kg cyclophosphamide resulted in permanent heart allograft acceptance in rats, whereas 50 mg/kg abolished immunologic enhancement.
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