Why the study?
Does pretransplant anti-CD4 monoclonal antibody therapy prolong the survival of cardiac allografts in rats?
Does pretransplant anti-CD4 monoclonal antibody therapy prolong the survival of cardiac allografts in rats?
Pretransplant anti-CD4 monoclonal antibody therapy induces specific, long-lasting unresponsiveness to fully MHC-mismatched cardiac allografts in rats without the need for additional immunosuppression.
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Preclinical tolerance induction with anti-CD4 therapy in rat cardiac allografts; leaves open translation to human transplantation.
Shizuru et al. (1990) studied this question.
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