Key result
Rheumatoid arthritis with continued low disease activity was not associated with a significantly higher prevalence of diastolic dysfunction compared to healthy controls (37.1% vs 30.3%, OR 1.4).
Why the study?
Left ventricular diastolic dysfunction is not anticipated in rheumatoid arthritis patients without cardiovascular disease symptoms and may be underdiagnosed, especially in those with low disease activity.
Does rheumatoid arthritis with low disease activity increase the prevalence of left ventricular diastolic dysfunction compared to healthy controls?
Population
70 RA patients with no CVD and low disease activity (DAS28 <= 3.2) and 33 healthy controls
Comparison
RA patients with low disease activity vs healthy controls
Authors
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May warrant LVDD screening in asymptomatic RA; leaves open whether detection improves outcomes in low-activity disease.
Cross-Sectional (n=103)
No
Does rheumatoid arthritis with low disease activity increase the prevalence of left ventricular diastolic dysfunction compared to healthy controls?
Odds Ratio: 1.4 (95% CI 0.6–3.3)
Absolute Event Rate: 37.1% vs 30.3%
p-value: p=NS
Patients with rheumatoid arthritis who maintain low disease activity do not exhibit a significantly higher prevalence of diastolic dysfunction compared to healthy controls, though longer disease duration and severity may increase risk.
Targońska‐Stępniak et al. (2018) conducted a cross-sectional in Rheumatoid arthritis with low disease activity (n=103). Rheumatoid arthritis with low disease activity vs. Healthy controls was evaluated on Abnormal E/A ratio (< 1.0) indicating diastolic dysfunction (OR 1.4, 95% CI 0.6-3.3, p=NS). Rheumatoid arthritis with continued low disease activity was not associated with a significantly higher prevalence of diastolic dysfunction compared to healthy controls (37.1% vs 30.3%, OR 1.4).
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