Key result
Rheumatoid arthritis was associated with a significantly higher prevalence of left ventricular diastolic dysfunction compared to healthy controls (37.3% vs 10.5%; P<0.05).
Why the study?
The study evaluated LV diastolic function parameters as an early predictor of cardiac involvement in RA patients without hypertension, diabetes, rheumatic fever, or underlying cardiac disease, and correlated them with RA characteristics.
Does rheumatoid arthritis increase the prevalence of left ventricular diastolic dysfunction in patients without underlying cardiac disease?
Population
75 RA patients without hypertension, diabetes, rheumatic fever, or cardiac disease and 38 matched controls
Comparison
RA patients vs age-matched and sex-matched healthy controls
Design
Case-control study
Authors
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Two clauses? Yes (Highlights... ; leaves open...).
Case-Control (n=113)
Does rheumatoid arthritis increase the prevalence of left ventricular diastolic dysfunction in patients without underlying cardiac disease?
Absolute Event Rate: 37.3% vs 10.5%
p-value: p=<0.05
Asymptomatic patients with rheumatoid arthritis have a significantly higher prevalence of left ventricular diastolic dysfunction compared to healthy controls, which correlates with disease duration and activity.
Ghaleb et al. (2019) conducted a case-control in Rheumatoid arthritis (n=113). Rheumatoid arthritis vs. Healthy controls was evaluated on Left ventricular diastolic dysfunction (transmitral flow E/A ratio < 1) (p=<0.05). Rheumatoid arthritis was associated with a significantly higher prevalence of left ventricular diastolic dysfunction compared to healthy controls (37.3% vs 10.5%; P<0.05).
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