Key result
Rheumatoid arthritis was associated with significantly prolonged isovolumetric relaxation time (MD 9.67 msec; 95% CI 5.78-13.56; P<0.00001) and other parameters of diastolic dysfunction.
Why the study?
Do patients with rheumatoid arthritis have an increased prevalence of echocardiographic parameters indicative of diastolic dysfunction compared to controls?
Population
5,836 subjects (1,614 with rheumatoid arthritis) from 25 studies
Comparison
Rheumatoid arthritis (RA) vs Controls (without RA)
Design
Meta-analysis
Authors
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Supports screening for diastolic dysfunction in rheumatoid arthritis; extends observational evidence via pooled echocardiographic parameters.
Meta-Analysis (n=5,836)
Do patients with rheumatoid arthritis have an increased prevalence of echocardiographic parameters indicative of diastolic dysfunction compared to controls?
Effect estimate: Mean difference 9.67 msec (95% CI 5.78, 13.56)
p-value: p=<0.00001
Patients with rheumatoid arthritis are more likely to exhibit echocardiographic parameters of diastolic dysfunction, higher systolic pulmonary artery pressures, and larger left atrial sizes compared to controls.
Aslam et al. (2012) conducted a meta-analysis in Rheumatoid arthritis (n=5,836). Rheumatoid arthritis vs. Controls was evaluated on Isovolumetric relaxation time (Mean difference 9.67 msec, 95% CI 5.78, 13.56, p=<0.00001). Rheumatoid arthritis was associated with significantly prolonged isovolumetric relaxation time (MD 9.67 msec; 95% CI 5.78-13.56; P<0.00001) and other parameters of diastolic dysfunction.
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