Key result
Rheumatoid arthritis was associated with significantly impaired diastolic function, including a reduced E/A ratio (0.9 vs 1.1, p=0.000) and increased left ventricular mass index, compared to healthy controls.
Why the study?
Rheumatoid arthritis can affect the cardiovascular system, and diastolic dysfunction is particularly important in heart failure with preserved ejection fraction; this study aimed to investigate echocardiographic diastolic dysfunction parameters in RA patients.
Do rheumatoid arthritis patients have worse echocardiographic diastolic dysfunction parameters compared to healthy controls?
Cross-Sectional (n=153)
Do rheumatoid arthritis patients have worse echocardiographic diastolic dysfunction parameters compared to healthy controls?
Absolute Event Rate: 0.9% vs 1.1%
p-value: p=0.000
Rheumatoid arthritis patients exhibit subclinical echocardiographic signs of diastolic dysfunction and increased left ventricular mass index compared to healthy controls, suggesting early myocardial involvement.
RA patients show subclinical LV changes; hypothesis-generating and requires longitudinal confirmation before screening implications.
Rheumatoid arthritis (RA) is a chronic, autoimmune inflammatory disorder which can also affect cardiovascular system. Cardiovascular system involvement can be seen in many forms such as pericarditis, myocarditis, coronary artery disease or heart failure. Diastolic dysfunction is especially important for preserved ejection fraction heart failure patients. With this study we aim to investigate echocardiographic diastolic dysfunction parameters in RA patients.77 RA patients and 76 control subjects without coronary artery disease, heart failure, valvular heart diseases were included for the study and echocardiography was performed. Interventricular septum (p=0.041), posterior wall diameter (p=0.008), left ventricular mass index (p=0.037) values were significantly higher and E wave (p=0.000), E/A (p=0.000), e' (p=0.018) values were significantly lower in RA patients compared to control group. In conclusion echocardiographic diastolic dysfunction parameters were declined in RA patients.
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Özge Turgay Yıldırım (2018) conducted a cross-sectional in Rheumatoid arthritis (n=153). Rheumatoid arthritis vs. Healthy controls was evaluated on E/A ratio (p=0.000). Rheumatoid arthritis was associated with significantly impaired diastolic function, including a reduced E/A ratio (0.9 vs 1.1, p=0.000) and increased left ventricular mass index, compared to healthy controls.