What is the clinical evidence from this study?

Study design: Other. Intervention: Hyperpolarizing steps and DIDS. Primary outcome: Time-dependent inward Cl- current and ClC-2 expression.

September 10, 2004AJP Gastrointestinal and Liver Physiology

Contribution of a time-dependent and hyperpolarization-activated chloride conductance to currents of resting and hypotonically shocked rat hepatocytes

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Key result

Rat hepatocytes express a time-dependent inward Cl- channel (ClC-2) that is activated by hyperpolarization and could provide a significant depolarizing influence.

Population

Rat hepatocytes, WIF-B cells, and HEK293T cells

Design

Preclinical

Authors

HAHadeer Adil AbbasMiddle Technical University HLHung D. LamMcGill University ALAnne‐Marie LemayInstitut Universitaire de Cardiologie et de Pneumologie de Québec

Discussion

Member takes

Implication

Does not support changes in clinical hepatology practice; leaves open ClC-2 contributions to human hepatocyte electrophysiology.

Structured PICO

Population

Rat hepatocytes, WIF-B cells, and HEK293T cells

Exposure

Electrophysiological and molecular approaches (patch electrode-voltage clamp, hyperpolarizing steps, DIDS)

Outcome

Identification and characterization of time-dependent inward Cl- currents and ClC-2 expressionsurrogate

Rat hepatocytes express a time-dependent inward Cl- channel (ClC-2) that could provide a significant depolarizing influence.

Cite This Study

Abbas et al. (2004) studied this question. Hyperpolarizing steps and DIDS was evaluated on Time-dependent inward Cl- current and ClC-2 expression. Rat hepatocytes express a time-dependent inward Cl- channel (ClC-2) that is activated by hyperpolarization and could provide a significant depolarizing influence.

synapsesocial.com/papers/6a93d7835e7ae87f038f9152 https://doi.org/10.1152/ajpgi.00226.2004

View Full Paper

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Contribution of a time-dependent and hyperpolarization-activated chloride conductance to currents of resting and hypotonically shocked rat hepatocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Contribution of a time-dependent and hyperpolarization-activated chloride conductance to currents of resting and hypotonically shocked rat hepatocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider