Key result
Resting muscle sympathetic nerve activity showed a negative correlation with age and disease duration in Parkinson's disease patients, unlike the positive correlation in controls.
Why the study?
How does muscle sympathetic nerve activity change with age and disease duration in patients with Parkinson's disease compared to healthy controls?
Case-Control (n=39)
How does muscle sympathetic nerve activity change with age and disease duration in patients with Parkinson's disease compared to healthy controls?
Sympathetic vasomotor function, as measured by MSNA, declines with age and disease duration in Parkinson's disease, contrasting with the age-related increase seen in healthy individuals.
Answers are grounded in this paper and cite their sources.
May signal PD-specific autonomic decline unlike normal aging; hypothesis-generating and should not yet change practice.
OBJECTIVE: To clarify the characteristics of sympathetic vasomotor function in Parkinson's disease by sympathetic neurographic analysis. METHODS: Muscle sympathetic nerve activity (MSNA) was recorded using a microneurographic technique at rest and during head up tilt in 18 patients with idiopathic Parkinson's disease and 21 healthy controls. RESULTS: Heart rate and blood pressure at rest did not differ between index and control subjects. The increase in these variables and MSNA in response to tilting was slightly blunted in the Parkinson's group. Resting MSNA showed a negative correlation with age in patients with Parkinson's disease (p<0.05) and a positive correlation with age in controls (p<0.01). There was a negative correlation between duration of disease or disability levels and MSNA (p<0.01). CONCLUSIONS: Sympathetic vasomotor function may be related to age and disease duration in Parkinson's disease.
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Kazumasa Shindo (2003) conducted a case-control in Idiopathic Parkinson's disease (n=39). Idiopathic Parkinson's disease vs. Healthy controls was evaluated on Muscle sympathetic nerve activity (MSNA) at rest and during head up tilt (p=<0.05). Resting muscle sympathetic nerve activity showed a negative correlation with age and disease duration in Parkinson's disease patients, unlike the positive correlation in controls.
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