Growth of the pulmonary autograft after the Ross operation in childhood
Key result
The pulmonary autograft after the Ross operation in children grew parallel to somatic growth, with annulus diameter increasing from 18 to 20 mm (P<0.004) and sinus from 29 to 34 mm (P<0.001).
Why the study?
Does the pulmonary autograft grow proportionally to somatic growth after the Ross operation in children?
Population
30 children undergoing aortic valve replacement with the pulmonary autograft as a root replacement
Design
Cohort
Follow-up
mean 4.3+/-2.6 years
Authors
Discussion
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Member takes
Implication
Supports Ross durability in children; extends observational data but leaves open randomized confirmation.
Study Design
Type
Cohort (n=30)
Structured PICO
Does the pulmonary autograft grow proportionally to somatic growth after the Ross operation in children?
P
Population
30 children (mean age 11.3 years) who underwent aortic valve replacement with a pulmonary autograft, followed for a mean of 4.3 years.
E
Exposure
Aortic valve replacement with the pulmonary autograft as a root replacement (Ross operation)
O
Outcome
Growth of the autograft (annulus and sinus diameter) and late dilatationsurrogate
Main Result
p-value: p=<0.004
The pulmonary autograft grows parallel to somatic growth without undue dilatation in children undergoing the Ross operation, maintaining excellent hemodynamics.
Cite This Study
Simon et al. (2001) conducted a cohort in Aortic valve disease requiring replacement (n=30). Ross operation (pulmonary autograft) was evaluated on Annulus and sinus diameter growth (p=<0.004). The pulmonary autograft after the Ross operation in children grew parallel to somatic growth, with annulus diameter increasing from 18 to 20 mm (P<0.004) and sinus from 29 to 34 mm (P<0.001).