Key result
Acute alcohol intoxication in otherwise healthy individuals is most commonly associated with reversible P-wave prolongation and QTc prolongation.
Why the study?
What are the electrocardiogram changes associated with acute alcohol intoxication in otherwise healthy patients?
Systematic Review (n=141)
What are the electrocardiogram changes associated with acute alcohol intoxication in otherwise healthy patients?
Acute alcohol intoxication in otherwise healthy individuals is most commonly associated with reversible P-wave and QTc prolongation.
Answers are grounded in this paper and cite their sources.
ECG monitoring may be warranted in acute intoxication; extends limited observational data on reversible changes but leaves arrhythmia risk open for prospective study.
BACKGROUND: Acute alcohol intoxication has been associated with cardiac arrhythmias but the electrocardiogram (ECG) changes associated with acute alcohol intoxication are not well defined in the literature. OBJECTIVE: Highlight the best evidence regarding the ECG changes associated with acute alcohol intoxication in otherwise healthy patients and the pathophysiology of the changes. METHODS: A literature search was carried out; 4 studies relating to ECG changes with acute alcohol intoxication were included in this review. RESULTS: Of the total 141 patients included in the review, 90 (63.8%) patients had P-wave prolongation, 80 (56%) patients had QTc prolongation, 19 (13.5%) patients developed T-wave abnormalities, 10 (7%) patients had QRS complex prolongation, 3 (2.12%) patients developed ST-segment depressions. CONCLUSION: The most common ECG changes associated with acute alcohol intoxication are (in decreasing order of frequency) P-wave and QTc prolongation, followed by T-wave abnormalities and QRS complex prolongation. Mostly, these changes are completely reversible.
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Raheja et al. (2018) conducted a systematic review in Acute alcohol intoxication (n=141). Acute alcohol intoxication vs. Unexposed controls or baseline was evaluated on P-wave prolongation. Acute alcohol intoxication in otherwise healthy individuals is most commonly associated with reversible P-wave prolongation (63.8%) and QTc prolongation (56%).
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