Key result
Quantitative trait loci on chromosomes 2, 3, 9, and 10 may influence circulating adiponectin concentrations in the Pima population, with the strongest linkage on chromosome 9p (LOD = 3.5).
Population
517 Pima Indians without diabetes, and an expanded cohort of 582 siblings including those with type 2…
Design
Other
Authors
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Hypothesis-generating for adiponectin regulation in Pima Indians; leaves open replication and clinical translation in broader populations.
Observational (n=582)
Effect estimate: LOD 3.5
Quantitative trait loci on chromosomes 2, 3, 9, and 10 may influence circulating adiponectin concentrations, accounting for significant heritability in the Pima population.
Lindsay et al. (2003) conducted an observational in Serum adiponectin levels (n=582). Genetic loci on chromosomes 2, 3, 9, and 10 was evaluated on Linkage to serum adiponectin concentrations (LOD 3.5). Quantitative trait loci on chromosomes 2, 3, 9, and 10 may influence circulating adiponectin concentrations in the Pima population, with the strongest linkage on chromosome 9p (LOD = 3.5).
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