Key result
Mechanical strain increased Endothelin-1 secretion in human endothelial cells (0.54 vs 0.22 ng/hr/10^6 cells) via transcription mediated predominantly by the protein kinase C pathway.
Population
Human umbilical vein endothelial cells (HUVECs) cultured on a flexible membrane base
Comparison
Cyclical mechanical strain vs Unstrained control cells
Design
Preclinical
Authors
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May link mechanical strain to endothelial ET-1 release via PKC; hypothesis-generating and leaves open in vivo relevance.
Absolute Event Rate: 0.54% vs 0.22%
Mechanical strain stimulates endothelin-1 secretion and gene expression in human endothelial cells predominantly via the protein kinase C pathway and extracellular calcium, providing a mechanism for vascular tone regulation.
Wang et al. (1995) studied this question. Mechanical strain vs. Unstrained control cells was evaluated on Endothelin-1 (Et-1) secretion. Mechanical strain increased Endothelin-1 secretion in human endothelial cells (0.54 vs 0.22 ng/hr/10^6 cells) via transcription mediated predominantly by the protein kinase C pathway.
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