Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 1, 1989Circulation

Diagnosis of deep venous thrombosis. A prospective study comparing duplex scanning to contrast venography.

View Full Paper
Ask AI
Bookmark
Share

Key result

Duplex scanning using the absence of phasicity of flow demonstrated 92% sensitivity and 92% specificity for diagnosing deep venous thrombosis compared to contrast venography.

Why the study?

Does duplex scanning accurately diagnose lower extremity deep venous thrombosis compared to contrast venography?

Population

47 patients evaluated for lower extremity deep venous thrombosis

Comparison

Duplex scanning vs Contrast venography (reference standard)

Design

Cohort, double-blind

Authors

LKLois A. KillewichScripps Research InstituteGBGeri BedfordUniversity of WashingtonKBKirk W. BeachUniversity of Washington

Discussion

Loading...

Member takes

Implication

May reduce venography use for suspected DVT; leaves open whether isolated phasicity criterion suffices without combined criteria or prospective validation.

Study Design

Type

Observational (n=47)

Blinding

Double-blind

Structured PICO

Does duplex scanning accurately diagnose lower extremity deep venous thrombosis compared to contrast venography?

P
Population
47 patients evaluated for suspected lower extremity deep venous thrombosis.
E
Exposure
Duplex scanning (assessing criteria: visualization of thrombus [T], absence of spontaneous flow [F], absence of phasicity of flow with respiration [P], and incompressibility of the vein [VC])
C
Comparator
Contrast venography (reference standard)
O
Outcome
Sensitivity and specificity of duplex scan criteria for diagnosing lower extremity deep venous thrombosissurrogate

Isolated criteria from duplex scanning are insufficient to diagnose DVT; combinations of criteria are more accurate, and equivocal or calf vein cases may require repeat scanning or contrast venography.

Limitations

  • Low specificity of vein incompressibility was secondary to cases in which normal veins were difficult to compress in the thigh.
  • All false-negative cases were from isolated calf vein thrombi.
  • Low specificity of vein incompressibility due to difficulty compressing normal veins in the thigh
  • False-negative cases occurred with isolated calf vein thrombi

Cite This Study

Killewich et al. (1989) conducted an observational in Lower extremity deep venous thrombosis (n=47). Duplex scanning vs. Contrast venography was evaluated on Sensitivity and specificity for deep venous thrombosis. Duplex scanning using the absence of phasicity of flow demonstrated 92% sensitivity and 92% specificity for diagnosing deep venous thrombosis compared to contrast venography.

synapsesocial.com/papers/6a93e91a65578a3bc5fec40ahttps://doi.org/10.1161/01.cir.79.4.810
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Replacement of Venography in Suspected Venous Thrombosis by Impedance Plethysmography and <sup>125</sup>I-Fibrinogen Leg Scanning1981 · 161 citations
  2. 2Roentgen Diagnosis of Venous Thrombosis in the Leg1972 · 753 citations
  3. 3Deep venous thrombosis: detection by probe compression of veins.1986 · 114 citations
  4. 4Real-time B-mode ultrasonography for better specificity in the noninvasive diagnosis of deep venous thrombosis.1986 · 99 citations
  5. 5B‐mode sonography of blood clots1982 · 78 citations