Key result
The new-generation PT method, which corrects for inhibition by inactive coagulation factors, reduced the average INR difference between Quick and Owren PT methods from 1.21 to 0.19 in patients on oral anticoagulant therapy.
Why the study?
Does a new-generation PT method measuring active coagulation factors improve INR harmonization between Quick and Owren PT methods in patients on oral anticoagulant therapy?
Does a new-generation PT method measuring active coagulation factors improve INR harmonization between Quick and Owren PT methods in patients on oral anticoagulant therapy?
Absolute Event Rate: 0.19% vs 1.21%
A new-generation PT method that measures active coagulation factors separately from inactive factors improves the harmonization of INR results between Quick and Owren PT methods, potentially enhancing the safety of oral anticoagulant therapy monitoring.
May enhance INR consistency in OAC monitoring; leaves open need for outcome validation before practice change.
Oral anticoagulant therapy (OAT) calls for continuous control by prothrombin time (PT) test, as the therapeutic range in INR units is very narrow. Warfarin (or coumarin) inhibits coagulation factor synthesis in the liver, but at the same time inactive coagulation factors are formed. The aim here was to measure "active coagulation factors" and inhibition in calibrator kits and patient plasmas by a new method for Quick and Owren PT.
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Horsti et al. (2008) studied Oral anticoagulant therapy (n=210). New-generation PT method (inhibition correction) vs. Traditional PT method (total INR) was evaluated on Average difference between Quick and Owren PT INR results. The new-generation PT method, which corrects for inhibition by inactive coagulation factors, reduced the average INR difference between Quick and Owren PT methods from 1.21 to 0.19 in patients on oral anticoagulant therapy.
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