Key result
EDTA plasma showed high correlation with citrate plasma for prothrombin time estimation using the Owren method (R2 > 0.99), allowing the use of a single EDTA tube for multiple assays.
Why the study?
Does EDTA plasma provide comparable Prothrombin Time measurements to citrate plasma using the Owren method in hospital and health center patients?
Population
123 paired patient samples from hospital and health center patients
Comparison
Prothrombin time measurement using EDTA plasma… vs Prothrombin time measurement using standard…
Design
Other
Authors
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May enable single-tube sampling for PT and hematology assays; leaves open prospective validation before routine adoption.
Observational (n=123)
Does EDTA plasma provide comparable Prothrombin Time measurements to citrate plasma using the Owren method in hospital and health center patients?
Effect estimate: R2 > 0.99
EDTA plasma can be used to measure PT with the Owren procedure if calibrated with normal EDTA plasma, potentially allowing a single tube for both hematologic and coagulation assays.
Juha Horsti (2000) conducted an observational in Patients requiring prothrombin time (PT) estimation (n=123). EDTA plasma vs. Citrate plasma was evaluated on Prothrombin time (PT) estimation correlation (R2 > 0.99). EDTA plasma showed high correlation with citrate plasma for prothrombin time estimation using the Owren method (R2 > 0.99), allowing the use of a single EDTA tube for multiple assays.
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