What does this research mean for the field?

Human pegivirus 1 (HPgV-1) is present at comparable prevalences in acute febrile patients (4.35%) and healthy blood donors (3.79%) in Midwestern Brazil, with circulating strains belonging to subgenotypes 2a and 2b. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Identify the prevalence and characterize the genomic sequences of Human Pegivirus 1 (HPgV-1) circulating among acute febrile patients and healthy blood donors in Mato Grosso, Brazil.

August 30, 2026Archives of VirologyOpen Access

Human pegivirus 1 in healthy blood donors and in acute febrile patients from Mato Grosso, Midwestern Brazil

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Authors

EPEduarda PavanUniversidade Federal de Mato Grosso MCM. Albert CarrascoUniversidade Federal de Mato Grosso JPJaneth Aracely Ramirez PavónUniversidade Federal de Mato Grosso

Discussion

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Implication

Cross-sectional study reveals comparable Human Pegivirus 1 prevalence in acute febrile individuals and healthy blood donors, highlighting potential risks to transfusion safety and public health.

Key Points

Identify the prevalence and characterize the genomic sequences of Human Pegivirus 1 (HPgV-1) circulating among acute febrile patients and healthy blood donors in Mato Grosso, Brazil.
Screened serum samples from acute febrile patients (n = 92, collected in 2019) and voluntary blood donors (n = 633, collected in 2022) using RT-qPCR targeting the conserved 5' UTR region.
Converted viral nucleic acid from 28 positive samples to ds-cDNA and performed high-throughput sequencing using the Illumina NextSeq platform.
HPgV-1 RNA was detected in 4.35% (4/92) of acute febrile patients (75.00% female, mean age 28.86 years) and in 3.79% (24/633) of blood donors (66.67% male, 54.17% aged 30–45 years).
Successfully recovered eight HPgV-1 genomic sequences (7,708 to 9,248 nucleotides), identifying two subgenotype 2a strains and six subgenotype 2b strains.

Cite This Study

Pavan et al. (2026) studied this question.

synapsesocial.com/papers/6a93f0f56c1a8fb52e79d925 https://doi.org/10.1007/s00705-026-06720-3

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August 30, 2026Archives of VirologyOpen Access

Human pegivirus 1 in healthy blood donors and in acute febrile patients from Mato Grosso, Midwestern Brazil

View Full Paper

Ask AI

Bookmark

Authors

EPEduarda PavanUniversidade Federal de Mato Grosso MCM. Albert CarrascoUniversidade Federal de Mato Grosso JPJaneth Aracely Ramirez PavónUniversidade Federal de Mato Grosso

Discussion

Member takes

Implication

Cross-sectional study reveals comparable Human Pegivirus 1 prevalence in acute febrile individuals and healthy blood donors, highlighting potential risks to transfusion safety and public health.

Key Points

Identify the prevalence and characterize the genomic sequences of Human Pegivirus 1 (HPgV-1) circulating among acute febrile patients and healthy blood donors in Mato Grosso, Brazil.
Screened serum samples from acute febrile patients (n = 92, collected in 2019) and voluntary blood donors (n = 633, collected in 2022) using RT-qPCR targeting the conserved 5' UTR region.
Converted viral nucleic acid from 28 positive samples to ds-cDNA and performed high-throughput sequencing using the Illumina NextSeq platform.
HPgV-1 RNA was detected in 4.35% (4/92) of acute febrile patients (75.00% female, mean age 28.86 years) and in 3.79% (24/633) of blood donors (66.67% male, 54.17% aged 30–45 years).
Successfully recovered eight HPgV-1 genomic sequences (7,708 to 9,248 nucleotides), identifying two subgenotype 2a strains and six subgenotype 2b strains.

Cite This Study

Pavan et al. (2026) studied this question.

synapsesocial.com/papers/6a93f0f56c1a8fb52e79d925 https://doi.org/10.1007/s00705-026-06720-3

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