Key result
HPgV-1 brain infection links to fatal progressive leukoencephalitis driven by cerebral white matter inflammation.
Why the study?
Etiologic diagnosis remains uncertain in 35% to 50% of encephalitis patients despite its global prevalence and disease burden.
Population
2 adult female patients with fatal leukoencephalitis associated with HPgV-1 brain infection
Design
Case report
Authors
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HPgV-1 may merit consideration in progressive leukoencephalitis differentials; single case report leaves open causality and broader relevance.
Case Report (n=2)
Human pegivirus-1 neuroadaptation should be considered in the differential diagnosis of progressive leukoencephalitis in humans.
Balcom et al. (2018) conducted a case report in Fatal leukoencephalitis associated with human pegivirus-1 (HPgV-1) brain infection (n=2). Human pegivirus-1 (HPgV-1) brain infection was evaluated on Clinical and molecular features. Human pegivirus-1 (HPgV-1) brain infection was associated with fatal progressive leukoencephalitis, characterized by inflammatory changes, lymphocyte infiltration, and gliosis in cerebral white matter.
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