What question did this study set out to answer?

To describe a case of encephalitis associated with human pegivirus in a patient with HIV and assess treatment effects.

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

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Case report shows HPgV-1 treatment improves encephalitis in immunocompromised individual, suggesting the need for further study.

To describe a case of encephalitis associated with human pegivirus in a patient with HIV and assess treatment effects.
HPgV RNA was detected in cerebrospinal fluid and brain tissue using metagenomic sequencing.
The patient received off-label treatment with sofosbuvir and ledipasvir for their condition.
The patient demonstrated sustained clinical improvement after treatment with sofosbuvir/ledipasvir.
Normalization of cerebrospinal fluid findings was observed following therapy.
Detectable HPgV RNA disappeared post-treatment.

Moulignier et al. (2026) studied this question.

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