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February 5, 2016SHILAP Revista de lepidopterologíaOpen Access

Evaluation of Viremia Frequencies of a Novel Human Pegivirus by Using Bioinformatic Screening and PCR

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Authors

DBDavid BonsallWGWilliam F. GregoryCICamilla L. C. Ip

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Overview

Retrospective screening reveals low human hepegivirus 1 viremia in parenterally exposed cohorts, suggesting lower transmissibility or faster viral clearance than related bloodborne viruses.

Key Points

  • To evaluate the prevalence and frequency of active human hepegivirus 1 (HHpgV-1) viremia in cohorts with significant parenteral exposure.
  • Performed retrospective bioinformatic screening using metagenomic sequence libraries of plasma samples.
  • Validated screening using parallel PCR with conserved primers targeting the nonstructural 3 (NS3) region of HPgV and HHpgV-1.
  • Analyzed plasma from a cohort of 150 hepatitis C virus (HCV)-positive case-patients and 195 persons with hemophilia exposed to nonvirally inactivated factor VII/IX.
  • Identified HHpgV-1 viremia in 2 of 150 HCV-positive individuals, alongside a 14% frequency of HPgV viremia.
  • Detected 1 HHpgV-1-positive individual among 195 persons with hemophilia (0.5%), compared to 18 HPgV-positive cases (9%).
  • Confirmed that active HHpgV-1 infections occur infrequently in blood relative to HCV and HPgV, even among individuals with substantial parenteral exposure.

Cite This Study

Bonsall et al. (2016) studied this question.

synapsesocial.com/papers/69dc5e504f901957bec1042chttps://doi.org/10.3201/eid2204.151812
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Also Consider

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  1. 1Shotgun metagenomics detects the human pegivirus complete genome in a pediatric patient with acute hepatitis of unknown etiology: a case report2025
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  3. 3In Silico Characterization of Two Human Pegivirus Proteins Highlights Similarities with Hepatitis C Virus and Possible Therapeutic Repurposing2026
  4. 4Characterization of near-complete human <i>Pegivirus</i> 2 (HPgV-2) genomes in individuals co-infected with hepatitis C virus (HCV) in Cameroon2026
  5. 5Near-Complete Genome Sequence of a Human Pegivirus Variant Isolated from a Hepatitis E Virus-Infected Patient2019 · 3 citations