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September 12, 2025Frontiers in GeneticsOpen Access

Shotgun metagenomics detects the human pegivirus complete genome in a pediatric patient with acute hepatitis of unknown etiology: a case report

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Authors

RVRoberta VazzanaAMAlessandra MularoniCVClaudia Vaiana

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Overview

Case report shows complete genome of human pegivirus in an infant with hepatitis, suggesting pathogenic potential.

Key Points

  • Metagenomic sequencing identified the complete genome of human pegivirus-1 in an infant with acute hepatitis.
  • Clinical symptoms included severe hepatitis alongside elevated transaminases and lymphocytosis, indicating infection.
  • Testing ruled out common hepatotropic viruses and metabolic disorders before identifying human pegivirus-1.
  • The case emphasizes metagenomic sequencing as a vital tool for diagnosing atypical pathogens in children.

Cite This Study

Vazzana et al. (2025) studied this question.

synapsesocial.com/papers/68d44b3f31b076d99fa55007https://doi.org/10.3389/fgene.2025.1653082
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