Bioactive Compounds and Cytotoxicity of Seed and Leaf Oils of Moringa oleifera

Moringa oleifera is a plant known for its bioactive properties and the potential of its oils for food, cosmetic, and pharmaceutical applications. This study evaluated the physicochemical, bioactive properties, and cytotoxicity effect in cells of Moringa oleifera seed and leaf oils. The oils had high levels of unsaturated fatty acids (70.9% in the seed and 70.6% in the leaf), with a predominance of linoleic acid. Both showed no cytotoxicity, with cell viability of over 70% in CHO‐K1 and HepG2 cells, but in HaCaT cells, the seed oil presented toxicity at a high concentration of 50 µg·mL −1 . Analysis of the phenolic profile showed a higher concentration of eugenol in both oils analyzed, with 864.80 and 787.64 µg·g −1 for the seed and leaf oils, respectively. The methanolic fractions showed higher antioxidant activity. The oils showed an antifungal effect against Candida albicans with minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values of 10 mg·mL −1 . The whole fraction stood out regarding enzyme inhibition, reaching up to 97.94% for α‐glucosidase. The results demonstrate the potential of Moringa oleifera oils for industrial applications, highlighting their antioxidant, antifungal, and enzyme inhibitory activity related to carbohydrate metabolism.