Characterisation of the Novel HLA‐A*23:163 Allele by Next‐Generation Sequencing

Q: What does this research mean for the field?

The novel HLA-A*23:163 allele differs from the established HLA-A*23:01:01:03 allele by a single nucleotide substitution at position 925 of the cDNA. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Elham Harfouch; Bénédicte Pare; Aicha Hamdaoui; Meriem Merabet; Laure Croisille

doi:10.1111/tan.70956

August 28, 2026HLAOpen Access

Characterisation of the Novel HLA‐A*23:163 Allele by Next‐Generation Sequencing

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Key Points

Characterize the novel human leukocyte antigen allele HLA-A*23:163 using next-generation sequencing.
Sequenced cDNA using next-generation sequencing platforms to examine the genetic profile of the novel allele.
Compared the resulting nucleotide sequence against the reference sequence of HLA-A*23:01:01:03.
Identified HLA-A*23:163 as a novel allele distinct from HLA-A*23:01:01:03.
Demonstrated that the sequence variation consists of a single nucleotide substitution located at position 925 of the cDNA.

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Implication

Genomic sequencing reveals a single nucleotide substitution forming the novel HLA-A*23:163 allele in human cDNA, expanding known human leukocyte antigen diversity.

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Cite This Study

Harfouch et al. (2026) studied this question.

synapsesocial.com/papers/6a93f1396c1a8fb52e79e039 https://doi.org/10.1111/tan.70956

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Characterisation of the Novel HLA‐A*23:163 Allele by Next‐Generation Sequencing

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Characterisation of the Novel HLA‐A*23:163 Allele by Next‐Generation Sequencing

Key Points

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Implication

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