November 30, 2025HLAOpen Access

Characterisation of the Novel HLA‐A*23:23:02 Allele by Next Generation Sequencing

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HLA-A*23:23:02 shows a unique synonymous substitution in exon 3 compared to HLA-A*23:23:01, highlighting its distinct nature.
Key evidence includes the specific genetic difference which could influence immune response.
Next Generation Sequencing was used for detailed allele characterization, providing precise genetic insights.
Further validation may enhance our understanding of HLA allele variations and their implications in transplantation.

Implication

Analysis uncovers a synonymous substitution in HLA-A*23:23:02 compared to HLA-A*23:23:01, indicating novel genetic distinctions.

HLA‐A*23:23:02 differs from the most closely related allele A*23:23:01 by a single synonymous substitution in exon 3.

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Kesherwani et al. (2025) studied this question.

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Analysis uncovers a synonymous substitution in HLA-A*23:23:02 compared to HLA-A*23:23:01, indicating novel genetic distinctions.

HLA‐A*23:23:02 differs from the most closely related allele A*23:23:01 by a single synonymous substitution in exon 3.