Key result
Intravenous heparin requirements to achieve adequate anticoagulation did not consistently change between admission and the second week of hospitalization in patients with acute myocardial infarction.
Why the study?
Does the heparin requirement to achieve adequate anticoagulation change between admission and the second week in patients with acute transmural myocardial infarction?
Observational (n=18)
Does the heparin requirement to achieve adequate anticoagulation change between admission and the second week in patients with acute transmural myocardial infarction?
In patients with acute transmural myocardial infarction, heparin requirements for adequate anticoagulation remain stable between admission and the second week of hospitalization.
Stable heparin requirements in acute MI may support consistent dosing; case-report data leave open confirmation in prospective studies.
Eighteen patients with acute transmural myocardial infarction were treated with intravenously administered heparin sodium to achieve the same standard of anticoagulation. Whole blood clotting times were obtained every two hours for the first 48 hours following hospitalization. Each of these patients had a second study during their second week of hospitalization. There was no consistent change in heparin requirement to achieve adequate anticoagulation immediately following admission and during the second week (ten days later). There was no demonstrable correlation between clotting time and heparin dosage once clinically adequate anticoagulant therapy had been achieved. Therapeutic benefits from anticoagulant therapy were not investigated in this study.
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J Pombo (1970) conducted an observational in Acute transmural myocardial infarction (n=18). Intravenous heparin sodium was evaluated on Change in heparin requirement to achieve adequate anticoagulation. Intravenous heparin requirements to achieve adequate anticoagulation did not consistently change between admission and the second week of hospitalization in patients with acute myocardial infarction.
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