Key result
Acute MI is linked to accelerated heparin clotting time in ~74% of patients.
Why the study?
Does acute myocardial infarction accelerate blood coagulation, and does Dicumarol therapy prolong the heparin clotting time?
Population
Cardiac patients with acute myocardial infarction studied within three weeks after the attack, cardiac…
Comparison
Dicumarol therapy vs Patients without acute myocardial infarction and…
Design
Cohort
Follow-up
Up to three weeks after the attack
Authors
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AMI-associated hypercoagulability may warrant caution with standard heparin dosing; leaves open whether adjusted protocols improve outcomes.
Observational
Does acute myocardial infarction accelerate blood coagulation, and does Dicumarol therapy prolong the heparin clotting time?
Absolute Event Rate: 74% vs 7.1%
Acute myocardial infarction is associated with accelerated blood coagulation as measured by heparin clotting time, which can be prolonged by Dicumarol therapy.
Rosenthal et al. (1952) conducted an observational in Acute myocardial infarction. Acute myocardial infarction vs. Cardiac patients without acute myocardial infarction was evaluated on Accelerated heparin clotting time (below 20 minutes). Acute myocardial infarction was associated with an accelerated heparin clotting time in 74% of patients, compared to 7.1% of cardiac patients without acute myocardial infarction.
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