Key result
Serum adenosine deaminase levels were independently and positively correlated with coronary artery calcification scores in patients with type 2 diabetes mellitus (r = 0.255, p < 0.001).
Why the study?
The study investigated the association between serum adenosine deaminase and coronary artery calcification in patients with type 2 diabetes mellitus.
Is serum adenosine deaminase associated with coronary artery calcification in patients with type 2 diabetes mellitus?
Cross-Sectional (n=459)
Is serum adenosine deaminase associated with coronary artery calcification in patients with type 2 diabetes mellitus?
Effect estimate: r = 0.255
p-value: p=<0.001
Serum adenosine deaminase levels are positively correlated with coronary artery calcification in patients with type 2 diabetes, suggesting its potential as a marker for atherosclerosis severity.
Hypothesis-generating link between adenosine deaminase and CAC in T2DM; leaves open any clinical role pending prospective data.
We investigated the association between serum adenosine deaminase and coronary artery calcification (CAC) in type 2 diabetes mellitus (T2DM) patients. The cross-sectional study included 459 patients with T2DM, the clinical and laboratory tests were performed, and all T2DM patients were separated into the 3 groups based on the tertile of serum adenosine deaminase levels. In the baseline data, the CAC score had statistically significant differences between the 3 groups (p < 0.001). Serum adenosine deaminase levels were positively correlated with CAC score in T2DM patients (r = 0.355, p < 0.001). The results of multiple linear regression analysis showed that serum adenosine deaminase was independent positively correlated with CAC score in T2DM patients (r = 0.255, p < 0.001). Receiver-operating characteristic curve analysis showed that area under curve was 0.750 to identify T2DM patients with CAC. Serum adenosine deaminase levels are correlated with CAC scores in T2DM patients, clinically, serum adenosine deaminase should be considered as an underlying marker to determine the severity of atherosclerosis in T2DM patients.
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Yu et al. (2021) conducted a cross-sectional in Type 2 diabetes mellitus (n=459). Serum adenosine deaminase levels vs. Lower tertiles of serum adenosine deaminase was evaluated on Coronary artery calcification (CAC) score (r = 0.255, p=<0.001). Serum adenosine deaminase levels were independently and positively correlated with coronary artery calcification scores in patients with type 2 diabetes mellitus (r = 0.255, p < 0.001).
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