Key result
A 2:1 mixture of enzymatically hydrolyzed Dendropanax morbiferus extract and unripe Rubus coreanus extract induced 130.7% maximal vasorelaxation in phenylephrine-precontracted rat aortic rings.
Why the study?
Antihypertensive drugs require long-term use and carry economic burdens and adverse effects, prompting the search for natural medications for treating hypertension.
Population
Precontracted rat aorta rings, hippocampal neurons, RAW 264.7 macrophages, and HUVECs
Comparison
DP vs Hy-DP vs 5-uRCK extracts and combinations
Design
Preclinical in vitro and ex vivo experimental study
Authors
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May support preclinical testing of natural antihypertensives; leaves open any clinical role pending rigorous trials.
Hy-DP and 5-uRCK exert antihypertensive effects through different endothelium-dependent or endothelium-independent mechanisms, suggesting potential as natural medications for blood pressure regulation.
Park et al. (2020) studied Hypertension (experimental model). Enzymatically hydrolyzed Dendropanax morbiferus extract (Hy-DP) and unripe Rubus coreanus extract (5-uRCK) vs. Vehicle/Baseline was evaluated on Vasorelaxation of phenylephrine-precontracted rat aortic rings. A 2:1 mixture of enzymatically hydrolyzed Dendropanax morbiferus extract and unripe Rubus coreanus extract induced 130.7% maximal vasorelaxation in phenylephrine-precontracted rat aortic rings.
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