Key result
BQ-123 dose-dependently attenuated the degree of damage to the gastric mucosa induced by cold-restraint-stress in rats, increasing gastric mucosa blood flow and decreasing the ulcer index (P<0.01).
Population
Rat model of gastric ulcer induced by cold-restraint-stress (CRS)
Comparison
BQ-123 administered via left femoral vein prior… vs Normal controls and untreated stressed animals
Design
Preclinical
Authors
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ETA antagonism may protect against stress-induced gastric injury in rats; leaves open translation to human stress ulcer prevention.
p-value: p=<0.01
BQ-123, an ETA receptor antagonist, dose-dependently attenuates stress-induced acute gastric mucosal lesions in rats by improving gastric mucosal blood flow.
Duan et al. (2004) studied Acute gastric mucosal lesions (stress ulcer). BQ-123 vs. Untreated animals / normal controls was evaluated on Gastric mucosa blood flow (GMBF) and ulcer index (UI) (p=<0.01). BQ-123 dose-dependently attenuated the degree of damage to the gastric mucosa induced by cold-restraint-stress in rats, increasing gastric mucosa blood flow and decreasing the ulcer index (P<0.01).
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