What is the clinical evidence from this study?

Study design: Other. Intervention: Induced hypertension and hypotension vs. Normotension. Primary outcome: Coronary reactive hyperaemia and coronary vascular resistance (p=<0.05).

What question did this study set out to answer?

To examine how variations in arterial pressure influence coronary reactive hyperaemia after brief periods of coronary artery occlusion.

June 16, 2006Experimental Physiology

Coronary reactive hyperaemia and arterial pressure in anaesthetized goats

Q: What are the key findings of this study?

In anaesthetized goats, hypertension induced by noradrenaline and hypotension induced by vena cava constriction or isoprenaline significantly reduced coronary reactive hyperaemia compared to normotension.

Q: What question did this study set out to answer?

To examine how variations in arterial pressure influence coronary reactive hyperaemia after brief periods of coronary artery occlusion.

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Key result

In anaesthetized goats, hypertension induced by noradrenaline and hypotension induced by vena cava constriction or isoprenaline significantly reduced coronary reactive hyperaemia compared to normotension.

Why the study?

Does arterial pressure alter coronary reactive hyperaemia following brief coronary occlusion in anaesthetized goats?

Population

Anaesthetized goats

Comparison

Hypertension and hypotension combined with 5… vs Normotension

Design

Preclinical

Authors

NFNúria FernándezUniversidad de Oviedo LMLuis MongeCornell University ÁGÁngel Luis Garcı́a-VillalónUniversidad Autónoma de Madrid

Discussion

Member takes

Implication

Arterial pressure modulates coronary reactive hyperaemia in goats; leaves open translation to human coronary assessments.

Key Points

To examine how variations in arterial pressure influence coronary reactive hyperaemia after brief periods of coronary artery occlusion.
Measured left circumflex coronary artery flow in anaesthetized goats during normotension, hypertension, and hypotension.
Assessed reactive hyperaemia following 5, 10, or 20 seconds of coronary artery occlusion under mechanical interventions (aortic or caudal vena cava constriction) and pharmacological infusions (noradrenaline or isoprenaline).
Aortic-constriction hypertension (MAP = 140 ± 6 mmHg) showed hyperaemic responses comparable to normotension, but noradrenaline-induced hypertension (MAP = 144 ± 6 mmHg) lowered coronary vascular resistance (CVR) by 16% and reduced reactive hyperaemia by 14–25% (P < 0.05).
Hypotension induced by vena cava constriction (MAP = 40 ± 4 mmHg) reduced CVR by 22% (P < 0.05) and reactive hyperaemia by 25–65% (P < 0.05) compared to normotension.
Isoprenaline-induced hypotension (MAP = 45 ± 4 mmHg) decreased CVR by 59% and suppressed reactive hyperaemia by 55–100% (P < 0.01) relative to normotensive values.

Structured PICO

Does arterial pressure alter coronary reactive hyperaemia following brief coronary occlusion in anaesthetized goats?

Population

Anaesthetized goats subjected to normotension, hypertension, and hypotension to study coronary reactive hyperaemia.

Intervention

Hypertension (induced by aortic constriction or noradrenaline) and hypotension (induced by constriction of the caudal vena cava or isoprenaline) combined with 5, 10, or 20 seconds of left circumflex coronary artery occlusion

Comparator

Normotension

Outcome

Coronary reactive hyperaemia (ratio of peak in hyperaemic flow to control flow and ratio of repayment to debt) and coronary vascular resistance (CVR)surrogate

Main Result

p-value: p=<0.05

Arterial pressure is a major determinant of coronary reactive hyperaemia following brief ischaemia, likely mediated by changes in coronary vascular resistance.

Cite This Study

Fernández et al. (2006) studied this question. Induced hypertension and hypotension vs. Normotension was evaluated on Coronary reactive hyperaemia and coronary vascular resistance (p=<0.05). In anaesthetized goats, hypertension induced by noradrenaline and hypotension induced by vena cava constriction or isoprenaline significantly reduced coronary reactive hyperaemia compared to normotension.

synapsesocial.com/papers/6a9401c2e5eea3f359d68bee https://doi.org/10.1113/expphysiol.2006.033480

Topics

Hypertension management

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Coronary reactive hyperaemia and arterial pressure in anaesthetized goats

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Topics

Coronary reactive hyperaemia and arterial pressure in anaesthetized goats

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider