Key result
Endogenous adenosine reaches mean concentrations of 128 +/- 26 nM in human subcutaneous tissue, which is sufficient to significantly decrease basal lipolysis in isolated human fat cells.
Endogenous adenosine reaches concentrations in human subcutaneous tissue sufficient to modulate lipolysis in vivo.
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May tonically inhibit lipolysis in human adipose tissue; leaves open therapeutic targeting in metabolic disease.
Lönnroth et al. (1989) studied Healthy (n=5). Microdialysis was evaluated on Mean interstitial adenosine concentration. Endogenous adenosine reaches mean concentrations of 128 +/- 26 nM in human subcutaneous tissue, which is sufficient to significantly decrease basal lipolysis in isolated human fat cells.
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