Key result
For measuring circulating adenosine in humans, a pharmacological blocker solution with a purpose-built syringe is the most sensitive technique, while microdialysis is suitable for interstitial tissue.
Standardizing methods for measuring in vivo adenosine concentrations could facilitate clinical translation of adenosine-modulating therapies for tissue protection.
No takes yet. Share an insight, caveat, or question.
May improve reproducibility of adenosine assays in research; leaves open standardization before clinical translation of modulating therapies.
Ramakers et al. (2008) reported a review. Measurement of endogenous adenosine concentration was evaluated. For measuring circulating adenosine in humans, a pharmacological blocker solution with a purpose-built syringe is the most sensitive technique, while microdialysis is suitable for interstitial tissue.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: